Extract of Reishi and Joint Inflammation
Reishi extract has been used in Traditional Chinese Medicine to treat arthritis and other forms of inflammation for over 2,000 years. Also commonly known by its Latin name as “Ganoderma,” or Chinese “Ling Zhi,” Reishi is by far the most searched medicinal mushroom on the Internet with over 200,000 searches per month. And although it may not be the panacea (“cure-all”) that some hold it to be, the fact that modern research confirms it as an inflammation modulator may help explain why it has long been heralded as such in the Orient.
Reishi frequently gets prescribed in Traditional Chinese Medicine for its analgesic, anti-inflammatory and anti-arthritic effects. Much recent research appears to validate this traditional use, as the majority of studies have yielded positive results. While looking through published articles on Reishi and arthritis, I found only two studies that showed inconclusive results, both of which were conducted by the same team of researchers. (1,2)
A U.S. based study conducted in 1993 showed that a water extract of Ganoderma lucidum (Reishi) exhibited “significant anti-inflammatory activity.” (4) Ten years later, an Indian research paper was published which stated that the use of Reishi extract helped decrease inflammation in acute edema by 56% and in chronic edema by 60%. (3) Using the “Article References” link on this page, you will find references to seven additional research articles that confirm Reishi extract as a powerful anti-inflammatory agent. (5,6,7,8,9,10,11)
Other Reishi studies have been performed which more directly relate to arthritis. A 2006 report by Kenneth Blum et al. provided support that clinical evidence demonstrates the effectiveness and safety of natural substances for joint health, such as glucosamine sulfate , chondroitin sulfate, and Ganoderma lucidum [Reishi]. (12)
The same year, another study summarized findings that Reishi in combination with a Chinese herbal remedy known as San-Miao-San demonstrated a positive “immunomodulatory effect” on rheumatoid arthritis. (13)
The answer as to how, precisely, Reishi extract accomplishes this “immunomodulatory effect” may have been given by another Chinese study the following year, which states that an isolated Reishi polysaccharide peptide “significantly inhibited” RASF, which is an indicator of rheumatoid arthritis. (RASF stands for “Rheumatoid Arthritis Synovial Fibroblasts.”) (14)
A number of other studies also report positive findings for using Reishi extract with arthritis (15,16,17) One of them even reports favorable results in comparing Reishi with prednisone, and without the side effects. (18) Furthermore, a different study found that supplementation with Reishi extract actually helped to balance the side effects of prednisolone experienced by some patients, including proteinuria and cell toxicity. (19) (Prednisone breaks down in the body to form prednisolone, which is the active compound.)
In conclusion, the body of research does seem to support the use of Reishi extract in cases of arthritis. Remember that it is important to always work with a licensed medical practitioner when using any herb for medicinal purposes.
Note: “Reishi” is the Japanese name on the mushroom known in English as “Varnished Conk.” It actually encompasses several closely related species, the most common of which is Ganoderma lucidum (Common Reishi or Red Reishi). This species can be found in the U.S. but is much more common in South East Asia. It is also well known by its Chinese name, Ling Zhi.
Other species frequently referred to as Reishi include: Ganoderma tsugae (Hemlock Reishi, common on Hemlocks in Eastern U.S.), Ganoderma sinense (“Black Reishi), Ganoderma resinaceum (Red Reishi), Ganoderma japonicum (Purple Reishi) and Ganoderma neo-japonicum (no common name or simply Reishi).